主な研究テーマ
放射線や抗がん剤で引き起こされる腫瘍内細胞死を低侵襲リアルタイムに可視化するシステムの開発と治療への応用
放射線や抗がん剤により腫瘍内で誘発される細胞死(アポトーシス、ネクローシス等)を可視化するシステムは、その光情報を指標とし、放射線治療条件の最適化および放射線化学療法の開発等、治療への応用に非常に有用な手段となる。本研究の目的は、腫瘍内細胞死を低侵襲かつリアルタイムに可視化するシステムを構築し、放射線治療臨床研究へ還元できる生物学的エビデンスを提示することである。
放射線や抗がん剤により腫瘍内で誘発される細胞死(アポトーシス、ネクローシス等)を可視化するシステムは、その光情報を指標とし、放射線治療条件の最適化および放射線化学療法の開発等、治療への応用に非常に有用な手段となる。本研究の目的は、腫瘍内細胞死を低侵襲かつリアルタイムに可視化するシステムを構築し、放射線治療臨床研究へ還元できる生物学的エビデンスを提示することである。

担当科目
学年 | 科目名 | 授業の目的 |
1 | 放射線生物学I | 何故、放射線によって癌の治療が可能なのか、言い換えれば、何故、放射線により細胞は死滅するのか。放射線による生物への影響の過程を分子、細胞、組織及び個体へと展開し、その機構を理解することを目標とする。 |
2 | 放射線生物学II | 何故、放射線によって癌の治療が可能なのか、言い換えれば、何故、放射線により細胞は死滅するのか。放射線による生物への影響の過程を分子、細胞、組織及び個体へと展開し、その機構を理解することを目標とする。 |
放射線管理学 | 放射線による障害防止のために必要な防護、施設等の基準、放射線同位元素を備える施設の管理技術および放射線の安全取扱法を理解する。 | |
放射線科学演習 | 「放射線物理学」「放射線生物学」「放射化学」「放射線安全管理学」で学んだ基礎的知識を整理し、放射線取扱主任者及び診療放射線技師になる為に必要な知識を身につける。 | |
放射線科学(医療検査学科) | 放射性同位元素(RI)を背景とした放射線基礎科学の基礎を習得し、RIに関連した臨床検査技術学について理解する。 | |
放射線科学(保健衛生学科) | 放射性同位元素と放射線は様々な分野で有効に利用されている一方、人体に対して有害な一面もある。放射性同位元素と放射線に関する基礎的事項(物理、化学、生物学)を理解した上で、放射線測定、放射性同位元素と放射線利用、放射線防護と関係法規、放射線安全管理の概要を学ぶことで、放射性同位元素と放射線を正しく理解することに役立てる。 | |
医療ケア安全管理学(臨床工学専攻) | 臨床工学技士として熟知すべき医療倫理とケア、および関連法令等の基本について理解する。 | |
放射線管理・計測学実習 | 広範多岐にわたる放射線計測機器の中から基本となる放射線測定器を選び、その特徴・特性及び放射線のもたらす現象を理解する。また、放射線による障害防止のために、医療用放射線施設に必要な防護、管理技術及び放射線の安全取扱法について習得する。 | |
3 | 放射線関係法規 | 放射線による障害防止のために必要な防護、施設等の基準、放射性同位元素を備える施設の管理技術および放射線の安全取扱法を理解することを目的とする。 |
4 | 放射線科学総合演習 | 最終学年の集大成として診療放射線技術科学の習熟度を統括的に把握し、さらなる知識の蓄積を図る。 |
卒業研究 | 与えられた研究テーマに自主的に取組み、個人またはグループで研究を進める。研究結果をまとめて口頭発表を行い、個人で卒業研究論文を作成する。 |
経歴・業績等
主な学歴・経歴
学歴2001年10月 - 2005年9月 | 富山医科薬科大学大学院 医学系研究科 博士課程 |
1999年10月 - 2001年9月 | 福井県立大学大学院 生物資源研究科 前期課程 |
1998年4月 - 1999年9月 | 筑波大学大学院 修士課程 バイオシステム研究科 |
1994年4月 - 1998年3月 | 福井県立大学 生物資源学部 |
経歴
2008年4月 - 現在 | 北里大学医療衛生学部/大学院医療系研究科 |
2006年7月 – 2008年3月 | 米国国立衛生研究所(NIH)/国立がん研究所(NCI)/放射線生物学部門(RBB) |
1999年4月 – 2006年6月 | 公益財団法人若狭湾エネルギー研究センター/粒子線医療研究室 |
主な業績
著書
1) 鍵谷 豪(分担執筆),新版 放射線医科学 -生体と放射線・電磁波・超音波-,医療科学社,pp8-10:2016.10
論文
1) T. Hirano, S. Adachi, N. Ichimura, A. Kasai, M. Kobayashi, T. Okuda, R. Ogawa, G. Kagiya (2021) Culturing Chinese hamster ovary cells on cyclo olefin polymer triggers epithelial-mesenchymal transition and spheroid formation, which increases the foreign gene expression driven by the MMLV-LTR promoter. Biotech. Prog. 37:e3159 doi: 10.1002/btpr.3159
2) G. Kagiya, A. Sato, R. Ogawa, M. Hatashita, M. Kato, M. Kubo, F. Kojima, F. Kawakami, Y. Nishimura, N. Abe and F. Hyodo (2021) Real-time visualization of intratumoral necrosis using split-luciferase reconstitution by protein trans-splicing. Mol. Ther. Oncolytics. 20:48-58, doi: 10.1016/j.omto.2020.12.001
3) R. Ogawa, G. Kagiya, A. Watanabe, A. Morii, Z. G. Cui and T. Kondo (2017) A simple method for constructing artificial promoters activated in response to ultrasound stimulation. Methods Mol Biol. 1651:187-203
4) G. Kagiya, R. Ogawa, F. Hyodo, K. Yamashita, M. Nakamura, A. Ishii, Y. Sejimo, S. Tominaga, M. Murata, Y. Tanaka and M. Hatashita (2016) Development of a real-time imaging system for hypoxic cell apoptosis. Mol. Ther. Methods Cli. Dev. 5: article number 16009 doi: 10.1038/mtm.2016.9
5) G. Kagiya, R. Ogawa, R. Choudhuri, J. A. Cook, M. Hatashita, Y. Tanaka, K. Koda, K. Yamashita, M. Kubo, F. Kawakami and J. B. Mitchell (2015) Selective enhancement of hypoxic cell killing by the tempol-regulated suicide gene expression. Oncol. Rep. 34:1065-1073 doi: 10.3892
6) M. Nakano, Y. Furusawa, A. Uzawa, Y. Matsumoto, R. Hirayama, C. Tsuruoka, T. Ogino, T. Nishio, K. Kagawa, M. Murakami, G. Kagiya, K. Kume, M. Hatashita, S. Fukuda, K. Yamamoto, H. Fuji, S. Murayama, M. Hata, T. Sakae, and H. Matsumoto (2014) Relative biological effectiveness of therapeutic proton beams for HSG cells at Japanese proton therapy facilities. J. Radiat. Res. 55(4):812-5 Doi: 10.1093/jrr/rru003
7) F. Kawakami, N. Shimada, E. Ohta, G. Kagiya, R. Kawashima, T. Maekawa, H. Maruyama and T. Ichikawa (2013) Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β. FEBS J 281(1): 3-13 Doi: 10.1111/febs.12579
8) R. Ogawa, A. Morii, A. Watanabe, Z. G. Cui, G. Kagiya, S. Fukuda, K. Kume, T. Hasegawa, M. Hatashita, H. Izumi, T. Ishimoto, L. B. Feril, Jr. (2013) Development of a therapeutically important radiation induced promoter. Bioengineered 4:1:44-49. doi: 10.4161/bioe.21965. Epub 2012 Aug 28
9) R. Ogawa, A. Morii, A. Watanabe, Z. G. Cui, G. Kagiya, T. Kondo, N. Doi, L. B. Feril, Jr. (2013) Regulation of gene expression in human prostate cancer cells with artificially constructed promoters that are activated in response to ultrasound stimulation. Ultrason Sonochem. 20:460-467. doi: 10.1016/j.ultsonch.2012.05.007. Epub 2012 May 24
10) R. Ogawa, A. Morii, A. Watanabe, Z. G. Cui, G. Kagiya, M. Hatashita, K. Kume, S. Fukuda, T. Hasegawa, T. Kondo. (2013) 放射線応答性遺伝子発現制御システムの開発, Japanese Journal of Radiation Biology Research Communications. 48(3): 267-279
11) R. Ogawa, A. Morii, A. Watanabe, Z. G. Cui, G. Kagiya, S. Fukuda, K. Kume, T. Hasegawa, M. Hatashita, H. Izumi, T. Ishimoto, and L.B. Feril. (2012) Regulation of gene expression in retrovirus vectors by X-ray and proton beam radiation with artificially constructed promoters. J Gene Med 14:316-327
12) R. Ogawa, A. Morii, A. Watanabe, Z. G. Cui, G. Kagiya, N. Doi, Q. L. Zhao, L. B. Feril, Jr. (2012) An artificially constructed radiation responsive promoter is activated with doxorubicin treatment. Cancer Gene Ther. 19: 345-351
13) F. Kawakami, M. Suzuki, N. Shimada, G. Kagiya, E. Ohta, K. Tamura, H. Maruyama and T. Ichikawa (2011) Stimulatory effect of α-Synuclein on the tau-phosphorylation by GSK-3β. FEBS J 278:4895-4904
14) G. Kagiya, R. Ogawa, J. A. Cook, R. Choudhuri, M. Hatashita, Y. Tanaka, B. G. DeGraff, and J. B. Mitchell. (2010) Improvement and induction property of radiation-responsive promoter through DNA shuffling of 5’-flanking regions of the human p21 gene. J. Biosci. Bioeng. 110:118-123
15) G. Kagiya, R. Ogawa, S. Ito, S. Fukuda, M. Hatashita, T. Yoshikazu, K. Yamamoto, and T. Kondo. (2009) Identification of a cis-acting element responds to ultrasound in 5’-flanking region of human heme oxygenase-1 gene. Ultrasound in Med. & Biol. 35: 155-164
16) R. Ogawa, S. Lee, H. Izumi, G. Kagiya, T. Yohsida, A. Watanabe, A. Morii, S. Kakutani, T. Kondo, L. B. Feril, Jr. and T. Ishimoto. (2009) Enhancement of artificial promoter activity by ultrasound-induced oxidative stress. Ultrasonics Sonochemistry 16: 379-386
17) A. Watanabe, S. Kakutani, R. Ogawa, Sung-il Lee, T. Yoshida, A. Morii, G. Kagiya, LB. Feril, Jr., H. Fuse and T. Kondo. (2009) Construction of artificial promoters sensitively responsive to sonication. J. Med. Ultrasonics. 36:9-17
18) R. Ogawa, S. Lee, G. Kagiya, H. Hirano, S. Fukuda, T. Kondo and T. Kodaki. (2008) Construction of X-ray inducible promoters through cis-acting element elongation and error-prone PCR. J. Gene Med. 10: 316-324
19) R. Ogawa, G. Kagiya, T. Kodaki, S. Fukuda and K. Yamamoto. (2007) Construction of strong mammalian promoters by random cis-acting element elongation. BioTechniques 42: 628-633
20) A. Uzawa, K. Ando, Y. Furusawa, G. Kagiya, H. Fuji, M. Hata, T. Sakae, T. Terunuma, M. Scholz, S. Ritter and P. Peschke. (2007) Biological intercomparison using gut crypt survivals for proton and carbon-ion beams. J. Radiat. Res. 48: A75-A80
21) G. Kagiya, R. Ogawa, Y. Tabuchi, L. B. Feril, Jr., T. Nozaki, S. Fukuda, K. Yamamoto, and T. Kondo. (2006) Expression of heme oxygenase-1 due to intracellular reactive oxygen species induced by ultrasound. Ultrasonics Sonochemistry 13: 388-396
22) G. Kagiya, Y. Tabuchi, L. B. Feril, Jr., R. Ogawa, Q. -L. Zhao, N. Kudo, W. Hiraoka, K Tachibana, S. Umemura, and T. Kondo. (2006) Confirmation of enhanced expression of heme oxygenase-1 gene induced by ultrasound and its mechanism: Analysis by cDNA microarray system, real-time quantitative PCR, and western blotting. J. Med. Ultrasonics. 33: 3-10
23) G. Kagiya, R. Ogawa, M. Hatashita, K. Takagi, T. Kodaki, S. Hiroishi, and K Yamamoto. (2005) Generation of a strong promoter for Escherichia coli from eukaryotic genome DNA. J. Biotechnol. 115: 239-248
24) R. Ogawa, G. Kagiya, L. B. Feril, Jr., N. Nakaya, T. Nozaki, H. Fuse, and T. Kondo. (2004) Ultrasound mediated intravesical transfection enhanced by treatment with lidocaine or heat. J. Urology. 172:1469-1473
25) N. Yokohama and G. Kagiya. (2004) Development of a radiation therapy information system and linked medical image server using techniques of WWW-DB. 日本放射線技術学会雑誌60: 835-841. Japanese
26) T. Nozaki, R. Ogawa, L. B. Feril, Jr., G. Kagiya, H. Fuse, and T. Kondo. (2003) Enhancement of ultrasound-mediated gene transfection by membrane modification. J. Gene Med. 5: 1046-1055
27) N. Yokohama, G. Kagiya, I. Maruyama, A. Nishijima and K. Yamamoto. (2003) New patient positioning system for proton therapy combined with CT with a common treatment couch. 日本放射線技術学会雑誌 59: 1432-1437. Japanese
28) K. Kagawa, M. Murakami, Y. Hishikawa, M. Abe, T. Akagi, T. Yanou, G. Kagiya, Y. Furusawa, K. Ando, K. Nojima, M. Aoki, and T. Kanai. (2002) Preclinical biological assessment of proton and carbon ion beams at Hyogo ion beam medical center. Int. J. Radiation Oncology Biol. Phys. 54: 928-938
29) R. Kondo, G. Kagiya, S. Hiroishi and M. Watanabe. (2000) Genetic typing of a bloom-forming cyanobacterial genus Microcystis in Japan using 16S rDNA gene sequence analysis. Plankton Biology and Ecology. 47: 1-6
30) R. Kondo, G. Kagiya, S. Hiroishi and M. Watanabe. (1999) Rapid DNA extraction from a bloom-forming cyanobacterium. Microbes and Environments. 14: 157-161
研究発表
1) A. Sato, M. Kato, R. Ogawa, M. Hatashita, F. Hyodo, M. Kubo and G. Kagiya,. Development of a non-invasive real time imaging system for hypoxic cell apoptosis. 16th International Congress of Radiation Research (Manchester, UK) 2019.8.25-29
2) G. Kagiya, R. Ogawa, M. Hatashita, Y. Tanaka, K. Yamashita, M. Nakamura, A. Ishii, Y. Sejimo. Development of non-invasive real-time imaging system of hypoxic cell apoptosis. 12th Meeting of the Asian Society for Neuro-Oncology (Manila, Philippines) 2015.9.17-20
3) G. Kagiya, R. Ogawa, M. Hatashita, Y. Tanaka, K. Yamashita, M. Nakamura, A. Ishii, Y. Sejimo. Development of non-invasive real-time imaging system of hypoxic cell apoptosis. 15th International Congress of Radiation Research (Kyoto) 2015.5.25-29
4) G. Kagiya, R. Ogawa, M. Hatashita, Y. Tanaka, K. Kouda, S. Fukuda, and J. B. Mitchell. Enhancement of hypoxic cell killing by the nitroxide Tempol. 10th International Congress on Targeted Anticancer Therapies (Amsterdam) 2012.3.8-10
5) G. Kagiya, R. Ogawa, S. Fukuda, K. Kume and K. Yamamoto:Differences of induction on human heme oxygenase-1 gene by proton beams and X-ray: XXXXIII PTCOG MEETING(Particle Therapy Co-operative Group), Munich, 2005.
6) G. Kagiya, K. Ando, M. Aoki, N. Endo, S. Fukuda, S. Fukumoto, Y. Furusawa, T. Hasegawa, M. Hatashita, S. Koike, K. Kume, K. Takagi, R. Uzawa, K. Yamamoto, and N. Yokohama:RBE values of 180 MeV proton beams at the Wakasa-Wan Energy Research Center(an interim report): XXXV PTCOG MEETING(Particle Therapy Co-operative Group), Tsukuba, 2001.
受賞
ベストティーチャー賞
1) 鍵谷 豪(分担執筆),新版 放射線医科学 -生体と放射線・電磁波・超音波-,医療科学社,pp8-10:2016.10
論文
1) T. Hirano, S. Adachi, N. Ichimura, A. Kasai, M. Kobayashi, T. Okuda, R. Ogawa, G. Kagiya (2021) Culturing Chinese hamster ovary cells on cyclo olefin polymer triggers epithelial-mesenchymal transition and spheroid formation, which increases the foreign gene expression driven by the MMLV-LTR promoter. Biotech. Prog. 37:e3159 doi: 10.1002/btpr.3159
2) G. Kagiya, A. Sato, R. Ogawa, M. Hatashita, M. Kato, M. Kubo, F. Kojima, F. Kawakami, Y. Nishimura, N. Abe and F. Hyodo (2021) Real-time visualization of intratumoral necrosis using split-luciferase reconstitution by protein trans-splicing. Mol. Ther. Oncolytics. 20:48-58, doi: 10.1016/j.omto.2020.12.001
3) R. Ogawa, G. Kagiya, A. Watanabe, A. Morii, Z. G. Cui and T. Kondo (2017) A simple method for constructing artificial promoters activated in response to ultrasound stimulation. Methods Mol Biol. 1651:187-203
4) G. Kagiya, R. Ogawa, F. Hyodo, K. Yamashita, M. Nakamura, A. Ishii, Y. Sejimo, S. Tominaga, M. Murata, Y. Tanaka and M. Hatashita (2016) Development of a real-time imaging system for hypoxic cell apoptosis. Mol. Ther. Methods Cli. Dev. 5: article number 16009 doi: 10.1038/mtm.2016.9
5) G. Kagiya, R. Ogawa, R. Choudhuri, J. A. Cook, M. Hatashita, Y. Tanaka, K. Koda, K. Yamashita, M. Kubo, F. Kawakami and J. B. Mitchell (2015) Selective enhancement of hypoxic cell killing by the tempol-regulated suicide gene expression. Oncol. Rep. 34:1065-1073 doi: 10.3892
6) M. Nakano, Y. Furusawa, A. Uzawa, Y. Matsumoto, R. Hirayama, C. Tsuruoka, T. Ogino, T. Nishio, K. Kagawa, M. Murakami, G. Kagiya, K. Kume, M. Hatashita, S. Fukuda, K. Yamamoto, H. Fuji, S. Murayama, M. Hata, T. Sakae, and H. Matsumoto (2014) Relative biological effectiveness of therapeutic proton beams for HSG cells at Japanese proton therapy facilities. J. Radiat. Res. 55(4):812-5 Doi: 10.1093/jrr/rru003
7) F. Kawakami, N. Shimada, E. Ohta, G. Kagiya, R. Kawashima, T. Maekawa, H. Maruyama and T. Ichikawa (2013) Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β. FEBS J 281(1): 3-13 Doi: 10.1111/febs.12579
8) R. Ogawa, A. Morii, A. Watanabe, Z. G. Cui, G. Kagiya, S. Fukuda, K. Kume, T. Hasegawa, M. Hatashita, H. Izumi, T. Ishimoto, L. B. Feril, Jr. (2013) Development of a therapeutically important radiation induced promoter. Bioengineered 4:1:44-49. doi: 10.4161/bioe.21965. Epub 2012 Aug 28
9) R. Ogawa, A. Morii, A. Watanabe, Z. G. Cui, G. Kagiya, T. Kondo, N. Doi, L. B. Feril, Jr. (2013) Regulation of gene expression in human prostate cancer cells with artificially constructed promoters that are activated in response to ultrasound stimulation. Ultrason Sonochem. 20:460-467. doi: 10.1016/j.ultsonch.2012.05.007. Epub 2012 May 24
10) R. Ogawa, A. Morii, A. Watanabe, Z. G. Cui, G. Kagiya, M. Hatashita, K. Kume, S. Fukuda, T. Hasegawa, T. Kondo. (2013) 放射線応答性遺伝子発現制御システムの開発, Japanese Journal of Radiation Biology Research Communications. 48(3): 267-279
11) R. Ogawa, A. Morii, A. Watanabe, Z. G. Cui, G. Kagiya, S. Fukuda, K. Kume, T. Hasegawa, M. Hatashita, H. Izumi, T. Ishimoto, and L.B. Feril. (2012) Regulation of gene expression in retrovirus vectors by X-ray and proton beam radiation with artificially constructed promoters. J Gene Med 14:316-327
12) R. Ogawa, A. Morii, A. Watanabe, Z. G. Cui, G. Kagiya, N. Doi, Q. L. Zhao, L. B. Feril, Jr. (2012) An artificially constructed radiation responsive promoter is activated with doxorubicin treatment. Cancer Gene Ther. 19: 345-351
13) F. Kawakami, M. Suzuki, N. Shimada, G. Kagiya, E. Ohta, K. Tamura, H. Maruyama and T. Ichikawa (2011) Stimulatory effect of α-Synuclein on the tau-phosphorylation by GSK-3β. FEBS J 278:4895-4904
14) G. Kagiya, R. Ogawa, J. A. Cook, R. Choudhuri, M. Hatashita, Y. Tanaka, B. G. DeGraff, and J. B. Mitchell. (2010) Improvement and induction property of radiation-responsive promoter through DNA shuffling of 5’-flanking regions of the human p21 gene. J. Biosci. Bioeng. 110:118-123
15) G. Kagiya, R. Ogawa, S. Ito, S. Fukuda, M. Hatashita, T. Yoshikazu, K. Yamamoto, and T. Kondo. (2009) Identification of a cis-acting element responds to ultrasound in 5’-flanking region of human heme oxygenase-1 gene. Ultrasound in Med. & Biol. 35: 155-164
16) R. Ogawa, S. Lee, H. Izumi, G. Kagiya, T. Yohsida, A. Watanabe, A. Morii, S. Kakutani, T. Kondo, L. B. Feril, Jr. and T. Ishimoto. (2009) Enhancement of artificial promoter activity by ultrasound-induced oxidative stress. Ultrasonics Sonochemistry 16: 379-386
17) A. Watanabe, S. Kakutani, R. Ogawa, Sung-il Lee, T. Yoshida, A. Morii, G. Kagiya, LB. Feril, Jr., H. Fuse and T. Kondo. (2009) Construction of artificial promoters sensitively responsive to sonication. J. Med. Ultrasonics. 36:9-17
18) R. Ogawa, S. Lee, G. Kagiya, H. Hirano, S. Fukuda, T. Kondo and T. Kodaki. (2008) Construction of X-ray inducible promoters through cis-acting element elongation and error-prone PCR. J. Gene Med. 10: 316-324
19) R. Ogawa, G. Kagiya, T. Kodaki, S. Fukuda and K. Yamamoto. (2007) Construction of strong mammalian promoters by random cis-acting element elongation. BioTechniques 42: 628-633
20) A. Uzawa, K. Ando, Y. Furusawa, G. Kagiya, H. Fuji, M. Hata, T. Sakae, T. Terunuma, M. Scholz, S. Ritter and P. Peschke. (2007) Biological intercomparison using gut crypt survivals for proton and carbon-ion beams. J. Radiat. Res. 48: A75-A80
21) G. Kagiya, R. Ogawa, Y. Tabuchi, L. B. Feril, Jr., T. Nozaki, S. Fukuda, K. Yamamoto, and T. Kondo. (2006) Expression of heme oxygenase-1 due to intracellular reactive oxygen species induced by ultrasound. Ultrasonics Sonochemistry 13: 388-396
22) G. Kagiya, Y. Tabuchi, L. B. Feril, Jr., R. Ogawa, Q. -L. Zhao, N. Kudo, W. Hiraoka, K Tachibana, S. Umemura, and T. Kondo. (2006) Confirmation of enhanced expression of heme oxygenase-1 gene induced by ultrasound and its mechanism: Analysis by cDNA microarray system, real-time quantitative PCR, and western blotting. J. Med. Ultrasonics. 33: 3-10
23) G. Kagiya, R. Ogawa, M. Hatashita, K. Takagi, T. Kodaki, S. Hiroishi, and K Yamamoto. (2005) Generation of a strong promoter for Escherichia coli from eukaryotic genome DNA. J. Biotechnol. 115: 239-248
24) R. Ogawa, G. Kagiya, L. B. Feril, Jr., N. Nakaya, T. Nozaki, H. Fuse, and T. Kondo. (2004) Ultrasound mediated intravesical transfection enhanced by treatment with lidocaine or heat. J. Urology. 172:1469-1473
25) N. Yokohama and G. Kagiya. (2004) Development of a radiation therapy information system and linked medical image server using techniques of WWW-DB. 日本放射線技術学会雑誌60: 835-841. Japanese
26) T. Nozaki, R. Ogawa, L. B. Feril, Jr., G. Kagiya, H. Fuse, and T. Kondo. (2003) Enhancement of ultrasound-mediated gene transfection by membrane modification. J. Gene Med. 5: 1046-1055
27) N. Yokohama, G. Kagiya, I. Maruyama, A. Nishijima and K. Yamamoto. (2003) New patient positioning system for proton therapy combined with CT with a common treatment couch. 日本放射線技術学会雑誌 59: 1432-1437. Japanese
28) K. Kagawa, M. Murakami, Y. Hishikawa, M. Abe, T. Akagi, T. Yanou, G. Kagiya, Y. Furusawa, K. Ando, K. Nojima, M. Aoki, and T. Kanai. (2002) Preclinical biological assessment of proton and carbon ion beams at Hyogo ion beam medical center. Int. J. Radiation Oncology Biol. Phys. 54: 928-938
29) R. Kondo, G. Kagiya, S. Hiroishi and M. Watanabe. (2000) Genetic typing of a bloom-forming cyanobacterial genus Microcystis in Japan using 16S rDNA gene sequence analysis. Plankton Biology and Ecology. 47: 1-6
30) R. Kondo, G. Kagiya, S. Hiroishi and M. Watanabe. (1999) Rapid DNA extraction from a bloom-forming cyanobacterium. Microbes and Environments. 14: 157-161
研究発表
1) A. Sato, M. Kato, R. Ogawa, M. Hatashita, F. Hyodo, M. Kubo and G. Kagiya,. Development of a non-invasive real time imaging system for hypoxic cell apoptosis. 16th International Congress of Radiation Research (Manchester, UK) 2019.8.25-29
2) G. Kagiya, R. Ogawa, M. Hatashita, Y. Tanaka, K. Yamashita, M. Nakamura, A. Ishii, Y. Sejimo. Development of non-invasive real-time imaging system of hypoxic cell apoptosis. 12th Meeting of the Asian Society for Neuro-Oncology (Manila, Philippines) 2015.9.17-20
3) G. Kagiya, R. Ogawa, M. Hatashita, Y. Tanaka, K. Yamashita, M. Nakamura, A. Ishii, Y. Sejimo. Development of non-invasive real-time imaging system of hypoxic cell apoptosis. 15th International Congress of Radiation Research (Kyoto) 2015.5.25-29
4) G. Kagiya, R. Ogawa, M. Hatashita, Y. Tanaka, K. Kouda, S. Fukuda, and J. B. Mitchell. Enhancement of hypoxic cell killing by the nitroxide Tempol. 10th International Congress on Targeted Anticancer Therapies (Amsterdam) 2012.3.8-10
5) G. Kagiya, R. Ogawa, S. Fukuda, K. Kume and K. Yamamoto:Differences of induction on human heme oxygenase-1 gene by proton beams and X-ray: XXXXIII PTCOG MEETING(Particle Therapy Co-operative Group), Munich, 2005.
6) G. Kagiya, K. Ando, M. Aoki, N. Endo, S. Fukuda, S. Fukumoto, Y. Furusawa, T. Hasegawa, M. Hatashita, S. Koike, K. Kume, K. Takagi, R. Uzawa, K. Yamamoto, and N. Yokohama:RBE values of 180 MeV proton beams at the Wakasa-Wan Energy Research Center(an interim report): XXXV PTCOG MEETING(Particle Therapy Co-operative Group), Tsukuba, 2001.
受賞
ベストティーチャー賞